Defining a new era of oligonucleotides

Defining a new era of oligonucleotides

Scientific Presentations

Scientific Presentations

Application of ADAR-mediated RNA editing to modulate protein-protein interactions
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European Society of Gene & Cell Therapy 29th Congress (October 2022)
RNA base editing for the treatment of Alpha-1 antitrypsin deficiency
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18th Annual Meeting of the Oligonucleotide Therapeutics Society (October 2022)
Stereopure oligonucleotides incorporating phosphoryl guanidine backbone increase durability of gene silencing by RNAi
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18th Annual Meeting of the Oligonucleotide Therapeutics Society (October 2022)
Effect of stereochemistry and backbone chemistry on AIMer RNA editing efficiency
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18th Annual Meeting of the Oligonucleotide Therapeutics Society (October 2022)
Phosphoryl-guanidine backbone chemistry: understanding its impact on stereopure oligonucleotides
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18th Annual Meeting of the Oligonucleotide Therapeutics Society (October 2022)
Synthesis of stereopure chimeric oligonucleotides containing PN and PS backbone: A systematic evaluation of chiral auxiliaries
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18th Annual Meeting of the Oligonucleotide Therapeutics Society (October 2022)
Synthesis and application of stereopure guanidine containing backbone to multiple oligonucleotide modalities in preclinical studies
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24th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids (August 2022)
Targeting pathological transcriptional variants in C9orf72-associated amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD): Initial results from the ongoing FOCUS-C9 clinical trial
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ENCALS Meeting (June 2022)
Stereopure AIMers for the treatment of Alpha-1 antitrypsin deficiency (AATD)
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TIDES USA: Oligonucleotides and Peptide Therapeutics (May 2022)
Chemically Optimized Stereopure Oligonucleotides Direct ADAR-mediated RNA Editing
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7TH ANNUAL OLIGONUCLEOTIDE & PRECISION THERAPEUTICS CONGRESS (March 2022)
A Novel Quantitative Wild-type Huntingtin (wtHTT) Protein Biomarker Method for Human Cerebrospinal Fluid
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CHDI 17TH ANNUAL HD THERAPEUTICS CONFERENCE (March 2022)
Innovations that Led to SELECT-HD, a Phase 1b/2a Clinical Trial of an Allele-selective Therapy for Huntington’s Disease
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CHDI 17TH ANNUAL HD THERAPEUTICS CONFERENCE (March 2022)
Towards the Development of a Therapeutic RNA Editing Platform
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3RD INTERNATIONAL CONFERENCE ON BASE EDITING – ENZYMES AND APPLICATIONS (DEAMINET 2022) (January 2022)
Chemically-optimized Stereopure Oligonucleotides Direct ADAR-mediated RNA Editing of SERPINA1 Transcripts, Yielding Functional Alpha-1 Antitrypsin Protein in a Mouse Model for Alpha-1 Antitrypsin Deficiency
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AASLD: THE LIVER MEETING (November 2021)
SELECT-HD: An Adaptive First-in-human Clinical Trial to Evaluate WVE-003, an Investigational Allele Selective mHTT-lowering Oligonucleotide, in Early Manifest Huntington's Disease
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28TH ANNUAL MEETING OF THE HUNTINGTON STUDY GROUP (November 2021)
Exploring New Oligonucleotide Backbone Chemistries and Their Deployment to Improve the Properties of Stereopure Oligonucleotides
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TIDES USA: OLIGONUCLEOTIDES & PEPTIDE THERAPEUTICS MEETING (September 2021)
Enhancing the Pharmacologic Profiles of CNS Targeting Therapeutic Oligonucleotides
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TIDES USA: OLIGONUCLEOTIDES & PEPTIDE THERAPEUTICS MEETING (September 2021)
Impact of Nitrogen-containing Backbone Linkages on Stereopure Antisense Oligonucleotides in the CNS
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TIDES USA: OLIGONUCLEOTIDES & PEPTIDE THERAPEUTICS MEETING (September 2021)
Chemically Optimized Stereopure Oligonucleotides Direct ADAR-mediated RNA Editing of SERPINA1 Transcripts, Yielding Functional Alpha-1 Antitrypsin Protein in a Mouse Model for Alpha-1 Antitrypsin Deficiency
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17TH ANNUAL MEETING OF THE OLIGONUCLEOTIDE THERAPEUTICS SOCIETY (September 2021)
A Versatile Platform for ADAR-mediated RNA Editing In Vivo in Preclinical Models
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17TH ANNUAL MEETING OF THE OLIGONUCLEOTIDE THERAPEUTICS SOCIETY (September 2021)
Predicting Exon Criticality from Primary Protein Structure
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17TH ANNUAL MEETING OF THE OLIGONUCLEOTIDE THERAPEUTICS SOCIETY (September 2021)
In Vitro Models for the Assessment of Antisense Oligonucleotide Induced Hepatotoxicity
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17TH ANNUAL MEETING OF THE OLIGONUCLEOTIDE THERAPEUTICS SOCIETY (September 2021)
Impact of Nitrogen-containing Backbone Linkages on Stereopure Antisense Oligonucleotides in the CNS
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17TH ANNUAL MEETING OF THE OLIGONUCLEOTIDE THERAPEUTICS SOCIETY (September 2021)
Allele-selective Reduction of Rho P23H-mutant Rhodopsin Rescues Phenotype Associated with Retinitis Pigmentosa in Preclinical Models
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17TH ANNUAL MEETING OF THE OLIGONUCLEOTIDE THERAPEUTICS SOCIETY (September 2021)
Variant-Selective Stereopure Oligonucleotides Protect Against Pathologies Associated with C9orf72-repeat Expansion in Preclinical Models
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KEYSTONE eSYMPOSIA: NEURODEGENERATIVE DISEASES: GENES, MECHANISMS AND THERAPEUTICS (June 2021)
A versatile platform for ADAR-mediated RNA editing in vivo in preclinical models
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AMERICAN SOCIETY OF GENE + CELL THERAPY 24TH ANNUAL MEETING (May 2021)
Design of an Adaptive Phase 1b/2a Randomized Controlled Trial of WVE-004 in Patients with C9orf72-ALS/FTD
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EUROPEAN NETWORK TO CURE ALS (ENCALS) VIRTUAL MEETING (May 2021)
A Ph1b/2a study of WVE-003, an investigational allele-selective, mHTT–lowering oligonucleotide for the treatment of early manifest Huntington’s disease, and review of PRECISION-HD results
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CHDI FOUNDATION 16TH ANNUAL HD THERAPEUTICS CONFERENCE (April 2021)
A Versatile Platform for ADAR-mediated RNA Editing in vivo in Preclinical Models
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KEYSTONE eSYMPOSIA: PRECISION ENGINEERING OF THE GENOME, EPIGENOME AND TRANSCRIPTOME (March 2021)
Stereopure Oligonucleotides in Development for the Treatment of Genetically Defined Diseases
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TIDES: OLIGONUCLEOTIDES AND PEPTIDE THERAPEUTICS 2020 MEETING (September 2020)
Stereopure oligonucleotides produce potent and durable activity in the eye supporting their development for inherited retinal diseases
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TIDES: OLIGONUCLEOTIDES AND PEPTIDE THERAPEUTICS 2020 MEETING (September 2020)
RNA Editing via Endogenous ADARs Using Stereopure Oligonucleotides
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1ST INTERNATIONAL CONFERENCE ON BASE EDITING - ENZYMES AND APPLICATIONS (DEAMINET 2020) (January 2020)