(State or other jurisdiction of

incorporation or organization)

(IRS Employer

Identification No.)

7 Straits View #12-00, Marina One East Tower

Singapore

William C. Hicks, Esq.

John T. Rudy, Esq.

John P. Condon, Esq.

Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.

One Financial Center

Boston, MA 02111

(617) 542-6000

Linda Rockett, Esq.

Senior Vice President, General Counsel

Wave Life Sciences Ltd.

c/o 733 Concord Avenue

Cambridge, MA 02138

(617) 949-2900

Amount

to be

Registered (1)

Proposed

Maximum

Offering Price

per Share

Proposed

Maximum

Aggregate

Offering Price (2)

Amount of

Registration Fee

Ordinary Shares, no par value per share

The number of Ordinary Shares of the Registrant (“Ordinary Shares”) stated above consists of (i) 53,000 shares issuable upon the exercise of share options (the “Inducement Options”) granted to a new employee pursuant to the Non-Qualified Share Option Agreement dated as of December 1, 2020 by and between the Registrant and the new employee (the “Inducement Option Agreement”) and (ii) 27,000 restricted share units (the “Inducement RSUs”) granted to the new employee pursuant to the Restricted Share Unit Agreement dated as of December 1, 2020 by and between the Registrant and the new employee (the “Inducement RSU Agreement”). The maximum number of shares which may be sold upon the exercise of the Inducement Options or upon the vesting of the Inducement RSUs is subject to adjustment in accordance with certain anti-dilution and other provisions of the Inducement Option Agreement and the Inducement RSU Agreement, respectively. Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the “Securities Act”), this Registration Statement shall also cover any additional Ordinary Shares that become issuable under the Inducement Option Agreement and the Inducement RSU Agreement, by reason of any share dividend, share split, recapitalization or other similar transaction effected without receipt of consideration that increases the number of the Registrant’s outstanding Ordinary Shares.

Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(h) and Rule 457(c) under the Securities Act. The offering price per share and the aggregate offering price for shares issuable upon the exercise of the Inducement Options are based upon $8.95, which is the exercise price for the Inducement Options, and the offering price per share and the aggregate offering price for shares issuable upon the vesting of the Inducement RSUs are based upon $4.73, which is the average of the high and low prices of the Ordinary Shares as reported on the Nasdaq Global Market on November 5, 2021. The chart below details the calculations of the registration fee.

Securities

Shares Underlying Inducement Options

Shares Underlying Inducement RSUs

Proposed Maximum Aggregate Offering Price

Registration Fee

FROM REGISTRATION CLAIMED.

Description

Previously filed as Exhibit 3.2 to Amendment No. 5 to the Registrant’s Registration Statement on Form S-1 (File No. 333-207379), filed with the Commission on November 10, 2015 and incorporated herein by reference.

Previously filed as Exhibit 4.1 to Amendment No. 3 to the Registrant’s Registration Statement on Form S-1 (File No. 333-207379), filed with the Commission on November 6, 2015 and incorporated herein by reference.

Previously filed as Exhibit 4.2 to the Registrant’s Registration Statement on Form S-1 (File No. 333-207379), filed with the Commission on October 9, 2015 and incorporated herein by reference.

Previously filed as Exhibit 10.2 to the Registrant’s Quarterly Report on Form 10-Q (File No. 001-37627), filed with the Commission on November 9, 2018 and incorporated herein by reference.

Previously filed as Exhibit 10.2 to the Registrant’s Quarterly Report on Form 10-Q (File No. 001-37627), filed with the Commission on August 15, 2016 and incorporated herein by reference. Confidential treatment has been granted with respect to certain portions of this exhibit. Omitted portions have been filed separately with the Commission.

Previously filed as Exhibit 10.3 to the Registrant’s Quarterly Report on Form 10-Q (File No. 001-37627), filed with the Commission on May 9, 2018 and incorporated herein by reference.

Previously filed as Exhibit 10.2 to the Registrant’s Quarterly Report on Form 10-Q (File No. 001-37627), filed with the Commission on May 9, 2018 and incorporated herein by reference.

Previously filed as Exhibit 10.3 to the Registrant’s Quarterly Report on Form 10-Q (File No. 001-37627), filed with the Commission on August 10, 2020 and incorporated herein by reference.

Previously filed as Exhibit 10.7 to the Registrant’s Quarterly Report on Form 10-Q (File No. 001-37627), filed with the Commission on November 10, 2021 and incorporated herein by reference.

Management contract or compensatory plan.

Signature

Title

Date

/s/ Paul B. Bolno, M.D., MBA

/s/ Kyle Moran

/s/ Christian Henry

/s/ Mark H. N. Corrigan, M.D.

/s/ Peter Kolchinsky, Ph.D.

/s/ Adrian Rawcliffe

/s/ Ken Takanashi

/s/ Gregory L. Verdine, Ph.D.

/s/ Aik Na Tan

/s/ Heidi L. Wagner, J.D.

WongPartnership LLP

12 Marina Boulevard Level 28

T +65 6416 8000

wongpartnership.com

FROM

The Board of Directors

Wave Life Sciences Ltd.

LJV/ONKC/20191271

f:+65 6532 5711

Not for service of court documents

Not for urgent correspondence

United States of America

d:+65 6416 6465

e:jenvern.loh@wongpartnership.com

Introduction

We have acted as legal advisers to the Company, a company incorporated under the laws of the Republic of Singapore, as to Singapore law in connection with the filing by the Company with the United States Securities and Exchange Commission (the “Commission”) of a registration statement on Form S-8 (the “Registration Statement”) under the Securities Act of 1933, as amended (the “Securities Act”), in respect of (i) 53,000 ordinary shares of the Company (the “Inducement Option Shares”) issuable upon the exercise of share options (the “Inducement Options”) granted to a new employee pursuant to the Non-Qualified Share Option Agreement dated 1 December 2020 entered into between the Company and the new employee (the “Inducement Option Agreement”), and (ii) 27,000 ordinary shares of the Company (the “Inducement RSU Shares”) issuable upon the vesting of restricted share units (the “Inducement Restricted Share Units”) granted to a new employee pursuant to the Restricted Share Unit Agreement dated 1 December 2020, as amended on 5 November 2021, entered into between the Company and the new employee (the “Inducement RSU Agreement”).

We do not express nor imply any opinion with respect to the effect of any law other than the laws of Singapore as of the date of this opinion, and have made no investigation of, and do not express or imply views of, any other laws which may be relevant to the documents submitted to us or opinions given by us, nor do we express or imply any opinion on matters relating to tax. This opinion is to be governed by and construed in accordance with the laws of Singapore as applied by the courts of Singapore as of the date of this opinion. All references to the laws of the Republic of Singapore or a specific law of the Republic of Singapore in this opinion are references to the laws of the Republic of Singapore as applied by the courts of the Republic of Singapore as of the date of this opinion. We are not obliged to update this opinion to reflect, or notify any addressee of this opinion or any other person of, any legal or legislative developments, or other changes to law or fact, arising after the date of this opinion. We have taken instructions solely from the Company.

In respect of the Inducement Option Agreement, the Inducement Options, the Inducement Option Shares, the Inducement RSU Agreement, the Inducement Restricted Share Units and the Inducement RSU Shares, we have assumed due compliance with all matters concerning the laws of the United

Documents

In rendering the opinions set out below, we have examined:

an electronic copy (in Adobe Acrobat form) of the certificate of incorporation of the Company dated 24 July 2012 issued by the Accounting and Corporate Regulatory Authority of Singapore (“ACRA”);

an electronic copy (in Adobe Acrobat form) of the certificate confirming incorporation upon conversion of the Company dated 6 November 2015 issued by ACRA confirming the Company’s conversion to a public company;

an electronic copy (in Adobe Acrobat form) of the constitution of the Company, as amended on 9 November 2015 (the “Constitutive Documents”);

an electronic copy (in Adobe Acrobat form) of the charter of the Compensation Committee of the Board of Directors of the Company;

electronic copies (in Adobe Acrobat form) of the minutes of a meeting of the Board of Directors of the Company held on 3 March 2020, 2 June 2020 and 15 April 2021 (the “Board Resolutions”);

electronic copies (in Adobe Acrobat form) of the resolutions in writing of the Compensation Committee of the Board of Directors of the Company dated 3 April 2020 and 21 October 2020 (the “Compensation Committee Resolutions”);

electronic copies (in Adobe Acrobat form) of certified true extracts of the resolutions of the shareholders of the Company dated 20 August 2020 and 18 August 2021 (the “Shareholders’ Resolutions” and together with the Board Resolutions and the Compensation Committee Resolutions, the “Resolutions”);

an electronic copy (in Adobe Acrobat form) of the Inducement Option Agreement;

an electronic copy (in Adobe Acrobat form) of the Inducement RSU Agreement;

an electronic copy (in Adobe Acrobat form) of the Registration Statement; and

such other documents as we may have considered necessary or desirable to examine in order that we may render this opinion.

This opinion is being rendered to you in connection with the filing of the Registration Statement. Except as expressly provided in paragraph 7 of this opinion, we express no opinion whatsoever with respect to any document described in paragraph 4 herein.

Assumptions

We have assumed (without enquiry and with your consent):

all signatures (including without limitation marks or text purporting to be signatures) (whether electronic or otherwise) on all documents submitted or made available to us (a) are genuine and authentic, (b) have not been altered or tampered with in any way, and (c) are in compliance

that each of the documents submitted or made available to us for examination and referred to in paragraph 4 above is a true, complete and up-to-date copy and has not been revoked, repudiated, terminated, amended or superseded, and all representations, warranties and factual statements contained therein are true and correct;

that the Resolutions were:

duly passed at properly convened meetings of duly appointed directors or the shareholders of the Company, or as the case may be, duly passed in the form of circulating resolutions in writing, in accordance with the provisions of the Constitutive Documents; and

duly passed in accordance with the provisions of the Companies Act, Chapter 50 of Singapore (the “Companies Act”);

that the copies of the Inducement Option Agreement and the Inducement RSU Agreement are true, complete and up-to-date, and have not been revoked, rescinded, superseded or amended and are in full force and effect and no other resolution or other action has been taken which could affect the validity of the Inducement Option Agreement or the Inducement RSU Agreement;

that the approvals conferred by the copies of the Resolutions submitted to us have not been revoked, rescinded, superseded or amended and are in full force and effect, and that no other resolution or other action has been passed or taken which could affect the validity of any or all of the Resolutions;

that the directors of the Company:

have been duly appointed in accordance with the provisions of the Companies Act and the constitution of the Company in force at that time;

have acted and will act in good faith and in the best interests of the Company in approving the preparation, execution and filing of the Registration Statement with the Commission, the entry into the transactions contemplated in the Inducement Option Agreement (including, but without limitation, the grant of the Inducement Options and issuance of the Inducement Option Shares) and the Inducement RSU Agreement (including, but without limitation, the grant of the Inducement Restricted Share Units and issuance of the Inducement RSU Shares), and without intention to defraud any of the creditors of the Company; and

have each disclosed and will disclose any interest which he may have in the Inducement Option Agreement, the Inducement Options, the Inducement Option Shares, the Inducement RSU Agreement, the Inducement Restricted Share Units and the Inducement RSU Shares, in accordance with the provisions of the Companies Act and the Constitutive Documents and except as disclosed, none of the directors of the

that all relevant documents have been provided to us by the officers of the Company for inspection for the purposes of this opinion;

that the grant of the Inducement Options and the issuance of the Inducement Option Shares are made under the Inducement Option Agreement and the Inducement Option Shares are duly issued in accordance with the requirements of applicable law (other than the laws of the Republic of Singapore in respect of the opinions in paragraph 7), the Inducement Option Agreement and the grant of the Inducement Options, and in compliance with Section 77 of the Companies Act;

that the grant of the Inducement Restricted Share Units and the issuance of the Inducement RSU Shares are made under the Inducement RSU Agreement and the Inducement RSU Shares are duly issued in accordance with the requirements of applicable law (other than the laws of the Republic of Singapore in respect of the opinions in paragraph 7), the Inducement RSU Agreement and the grant of the Inducement Restricted Share Units;

that, at the time of the grant of the Inducement Options and issuance of the Inducement Option Shares, and at the time of the grant of the Inducement Restricted Share Units and issuance of the Inducement RSU Shares, the Company has obtained a mandate from shareholders of the Company to issue ordinary shares of the Company pursuant to Section 161 of the Companies Act (the “Share Issue Mandate”) and such Share Issue Mandate has not expired in accordance with its terms or been previously revoked or varied by the Company in general meeting;

that the Inducement Option Shares to be issued under the Inducement Option Agreement and the Inducement RSU Shares to be issued under the Inducement RSU Agreement will be duly registered in the names of the persons who had been (i) granted the Inducement Options and issued the Inducement Option Shares, and (ii) granted the Inducement Restricted Share Units and issued the Inducement RSU Shares, respectively, or in the name of the Depository Trust Company or its nominee, as the case may be, and the certificates for the Inducement Option Shares and the Inducement RSU Shares will be duly issued and delivered;

that no law (including, without limitation, any public policy) of any jurisdiction outside Singapore is relevant to or affects the opinions expressed or conclusions stated in this opinion;

that there shall be the absence of fraud, bad faith, undue influence, coercion or duress on the part of the Company and its respective officers, employees, agents and advisers;

that all acts, conditions or things required to be fulfilled, performed or effected in connection with the allotment and issue of the Inducement Option Shares and the Inducement RSU Shares under the laws of any jurisdiction (other than by the Company under the laws of the Republic of Singapore in relation to the matters set out in paragraph 7 of this opinion) will be duly fulfilled, performed and complied with;

that there are no provisions of the laws of any jurisdiction (other than the laws of the Republic of Singapore in relation to the matters set out in paragraph 7 of this opinion) which will be contravened by the allotment and issue of the Inducement Option Shares and the Inducement RSU Shares and that, insofar as any obligation expressed to be incurred or performed under the Inducement Option Agreement and the Inducement RSU Agreement, and to the extent relevant, in connection with the allotment and issue of the Inducement Option Shares and the Inducement RSU Shares respectively, falls to be performed in or is otherwise subject to the

that all applicable consents, approvals, authorisations, licences, exemptions or orders required from any applicable governmental or other regulatory authorities and all other requirements for allotment and issue of the Inducement Option Shares and the Inducement RSU Shares (other than those required by the Company under the laws of the Republic of Singapore in relation to the matters set out in paragraph 7 of this opinion) have been (and have not been withdrawn) or will be duly obtained or fulfilled, and are (and will remain) in full force and effect, and that any conditions to which they are subject have been (or will be) satisfied;

that there are no agreements, documents, arrangements or transactions to which the Company is a party to that may in any way prohibit or restrict the allotment and issue of the Inducement Option Shares and the Inducement RSU Shares;

that the Constitutive Documents will not be amended in a manner that would have the effect of rendering any of our opinions in paragraph 7 inaccurate;

that valid consideration has been furnished for the entry into the Inducement Option Agreement and the Inducement RSU Agreement;

that no foreign law is relevant to or affects the conclusions stated in this opinion, and none of the opinions expressed herein will be affected by the laws (including, without limitation, the public policy) of any jurisdiction outside the Republic of Singapore, and insofar as the laws of any jurisdiction outside the Republic of Singapore may be relevant, such laws have been or will be complied with; and

that none of the Inducement Option Agreement, the Inducement Options, the Inducement Option Shares, the Inducement RSU Agreement, the Inducement Restricted Share Units, the Inducement RSU Shares or any of the transactions contemplated under the Inducement Option Agreement, the Inducement RSU Agreement, the options granted under the Inducement Option Agreement and the Inducement Restricted Share Units granted under the Inducement RSU Agreement constitutes or will constitute a sham.

Opinion

Based on the foregoing, and subject to the assumptions, limitations and qualifications set forth herein and having regard to such legal considerations as we have deemed relevant and subject to any matters not disclosed to us, we are of the opinion that:

the Inducement Option Shares will, when issued and delivered by the Company in accordance with the Constitutive Documents, the terms of the Inducement Option Agreement, and pursuant to the laws of Singapore against payment of such amounts required in accordance with the Inducement Option Agreement and the Inducement Options, be validly issued, fully paid and non-assessable; and

the Inducement RSU Shares will, when issued and delivered by the Company in accordance with the Constitutive Documents, the terms of the Inducement RSU Agreement, and pursuant to the laws of Singapore, be validly issued, fully paid and non-assessable.

Qualifications

This opinion is subject to the following qualifications:

for the purposes of this opinion, we have assumed that the term “non-assessable” (a term which has no recognised meaning under the laws of the Republic of Singapore) in relation to the Inducement Option Shares and the Inducement RSU Shares to be issued means that holders of such shares, having fully paid up all amounts due on such shares, or such shares having been credited as fully paid up, as the case may be, are under no further personal liability to make payments to the Company or its creditors or contribute to the assets or liabilities of the Company in their capacities purely as holders of such shares;

we are not responsible for, and have not investigated or verified, the accuracy or completeness of the facts and information, including any statements of foreign law, or the reasonableness of any assumptions, statements of opinion or intention, contained in the documents referred to in paragraph 4 of this opinion. We do not express any opinion as to any matters of fact generally, including statements of foreign law, or the reasonableness of any assumptions or statements of opinion or intention, contained in the documents described in paragraph 4. In addition, we are not responsible for investigating or verifying whether any material fact has been omitted from such documents;

we express no opinion as to the validity, binding effect or enforceability of any provision in the Inducement Option Agreement, the Inducement RSU Agreement, the Inducement Options or, where applicable, the Inducement Option Shares, the Inducement Restricted Share Units or the Inducement RSU Shares by reference to a law other than that of the Republic of Singapore, or as to the availability in the Republic of Singapore of remedies which are available in other jurisdictions;

with respect to matters of fact material to this opinion, we have relied on the statements of the responsible officers of the Company;

we have only examined a copy of the Registration Statement and not the information or documents incorporated by reference to the Registration Statement, except as otherwise listed in paragraph 4 of this opinion; and

this opinion is strictly limited to matters stated in this opinion and is not to be construed as extending (by implication or otherwise) to the documents listed in paragraph 4 of this opinion, or to any other matter or document in connection with, referred to, contemplated by or incorporated by reference, in such documents.

We hereby consent to the use of our opinion as herein set forth as an exhibit to the Registration Statement. In giving this consent, we do not hereby admit and shall not be deemed to admit that we come within the category of persons whose consent is required under Sections 7 and 11 of the Securities Act or to the rules and regulations of the Commission thereunder.

This opinion is only for the benefit of the person to whom it is addressed, subject to the condition that such person accepts and acknowledges that this opinion may not be appropriate or sufficient for such person’s purposes, and is strictly limited to the matters stated in this opinion and is not to be read as extending by implication to any other matter in connection with the Inducement Option Agreement and the Inducement RSU Agreement, or otherwise, including, but without limitation, any other document (including the Registration Statement). Further, except for the filing of this opinion with the Commission as an exhibit to the Registration Statement, this opinion is not to be circulated to, or relied upon by, any other person (other than persons entitled to rely on it pursuant to applicable provisions of federal