SECURITIES AND EXCHANGE COMMISSION
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|Item 8.01|| |
On December 21, 2020, Wave Life Sciences Ltd. (the “Company”) disclosed that it has initiated clinical development of WVE-003 with the submission of a clinical trial application (CTA). WVE-003 is the Company’s investigational allele-selective silencing candidate targeting an undisclosed single nucleotide polymorphism on the mutant Huntingtin mRNA transcript (SNP3), which is being developed for the treatment of Huntington’s disease.
Also on December 21, 2020, the Company disclosed that it has initiated clinical development of WVE-004 with the submission of a CTA. WVE-004 is the Company’s investigational variant-selective silencing candidate targeting transcript variants containing the hexanucleotide repeat expansion (G4C2) in the C9orf72 gene, which is being developed for the treatment of amyotrophic lateral sclerosis and frontotemporal dementia.
WVE-003 and WVE-004 are the Company’s first clinical programs to utilize novel PN backbone chemistry, an advancement in rational drug design from Wave’s PRISMTM discovery and drug development platform. In preclinical experiments, judicious use of PN backbone chemistry modifications in stereopure oligonucleotides has generally increased potency, exposure and durability across the Company’s silencing, splicing and editing modalities.
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
|WAVE LIFE SCIENCES LTD.|
|Paul B. Bolno, M.D.|
|President and Chief Executive Officer|
Date: December 21, 2020